Programmatic Introduction of the BPaL Regimen: A Practical Implementation Guide

Download Guideline
Published: November 2022

Authors: Staples S, Khan M. Howell, P; Juneja, S. Gupta, A

In 2021, Dr Suzanne Staples and Dr Munira Khan co-authored a practical implementation guide for use in the programmatic introduction of the BPaL regimen, with key contributions from Dr Pauline Howell (WITS Health Consortium), Sandeep Juneja and Aastha Gupta (TB Alliance) amongst others. This regimen, consisting of Bedaquiline, Pretomanid and Linezolid, is becoming increasingly accessible on a global scale for the treatment of drug- resistant tuberculosis and the guide is intended to assist countries in planning for BPaL implementation. The guide is available in English and Russian for broader use globally.

The development of this implementation guide was supported by the Stop TB Partnership’s TB REACH initiative and was funded by the Government of Canada, the Bill & Melinda Gates Foundation, and the United States Agency for International Development.